World-class research center ‘Center for Personalized Medicine’

The world-class scientific center ‘Center for Personalized Medicine’ was created on the basis of the consortium of the Federal State Budgetary Scientific Institution ‘Institute of Experimental Medicine’ and the Federal State Budgetary Institution ‘Almazov National Medical Research Centre’

Dmitriev Alexander Valentinovich

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Director of the Institute of Experimental Medicine, Doctor of Biological Sciences, Professor of the Russian Academy of Sciences

The number of publications (RSCI) – 113, Hirsch index (RSCI) – 13, RSCI Author ID: 90079 Number of publications (WOS) – 47, Hirsch index (WOS) – 11, WOS Researcher ID: C-9407-2012 Number of publications (Scopus) – 43, Hirsch index (Scopus) –11, Scopus Author ID –56346047800 ORCID ID: 0000-0002-6214-9770

Main academic interests:

Molecular biology, molecular epidemiology, genetics, genetic engineering, regulation of transcription, mechanisms of the formation of virulence of pathogenic microorganisms.

Education:

  • In 1993 he graduated from the St. Petersburg Institute of Technology, Department of Molecular Biotechnology, specialty – biotechnology.
  • In 1997 defended Ph.D. thesis on the topic ‘Genetic characteristics of group B streptococci; genome mapping’
  • In 2004 defended doctoral dissertation ‘Genomic polymorphism of group B streptococcus – the causative agent of human and animal diseases’.
  • Since 1991, he has been working at the Institute of Experimental Medicine. Nowadays Alexander Valentinovich holds the position of director of the FSBSI ‘IEM’.

Expert:

  • expert of the Ministry of Science and Higher Education, the Russian Academy of Sciences,
  • expert of the Russian Foundation for Basic Research,
  • expert of the Russian Science Foundation,
  • expert of the Scientific Research Institute – Federal Research Centre for Projects
Evaluation and Consulting Services

International scientific cooperation and scientific trips:

  • Beijing Children’s Hospital, China (1995; 1998; 1999-2000; 2001; 2002; 2003; 2004; 2005; 2006; 2009; 2010; 2011; 2015): executive in charge of a project to study the genetics of group B streptococci;
  • University of Veterinary Medicine, Kosice, Slovakia (1999; 2002; 2003): responsible person in the framework of the project on the study of the genetics of pathogenic microorganisms;
  • University of South Dakota, University of Kansas, USA (2005-2006; 2007-2008; 2009): scientific collaboration in the field of transcription regulation in pathogenic streptococci;
  • University of Budapest, Hungary (2009): training course on nanotechnology using robots;
  • Liconic Ltd, Manchester, UK (2012): visit to Tekan cryostorage;
  • Joint Russian-Vietnamese Tropical Center, Vietnam (2012; 2013; 2014; 2015): head and executive officer of research projects in the field of infectious diseases;
  • Lisbon, Portugal (2012; 2013; 2014; 2015): cooperation on the international project PIRSES-GA-2010-269138;
  • Düsseldorf (2013): visit to the clinic of the University of Düsseldorf;
  • Tartu (2014): visit to the University of Tartu;
  • Karlsruhe (2014): visit to the University of Karlsruhe;
  • Shijiazhong (2015, 2017): Visiting a biotechnology company in Shijiazhon;
  • Magdeburg (2017): visit to the University of Magdeburg;
  • Beijing, Jinan, Changchun, Guangzhou (2018): visits to institutes and biotechnology industries.

Participation in foreign conferences:

Slovakia (1996, 2001, 2010), France (1996), Germany (1997, 2019), Italy (2003, 2013), USA (2005, 2007), Greece (2008), Finland (2009), Portugal (2013), Argentina (2014), China (2015, 2016), Holland (2016), Belarus (2018), Slovenia (2019).

Participation in projects as a performer:

RFBR projects 00-04-49360, 03-04-49760, 06-04-08026, 06-04-48949, 09-04-13556, 10-04-06828, 10-04-07003, projects NSh-2206.2003.4 and 223.2012.7, project VEGA 1-8021-01, project PIRSES-GA-2010-269138, grants NIAID / NIH RO1 AIO52147 and NIDCR DE016686, grant from St. Petersburg State University No. 51094520.

Personal achievements

In the course of many years of research, data on the mechanisms of the pathogenesis of streptococcal diseases have been obtained and the possibility of transmission of streptococci from animals to humans and from humans to animals has been scientifically substantiated. The whole genome sequences, transcriptomes and proteomes of microorganisms were characterized. The influence of protein regulators and mutational processes on the evolution and virulent properties of microorganisms has been investigated. New targets have been identified with the aim of creating innovative antibacterial drugs. The genetic diversity of pathogens of infectious diseases in the tropics has been studied. As a result of this research, methods for identifying epidemically significant clones of microorganisms have been introduced into the practice of domestic and foreign medical institutions.

Main publications

  • Belopolskaya M.A., Avrutin V.Yu., Rukoyatkina E.A., Dmitriev A.V. Chronic hepatitis B and C in women: features of the course of pregnancy, childbirth and morphological characteristics of the placenta. Archive of Internal Medicine. 2018.T 1. – 22p. doi.org/10.20514/2226-6704-2018-8-1-22-28 https://www.medarhive.ru/jour/article/view/742
  • Kireeva A.G., Kalinina O.V., Kiselev A.M., Briko N.I., Glushkova E.V., Dmitriev A.V. Prevalence of the ICE-emm12 genetic element, containing the tetM and ermB resistance genes, among Russian and Vietnamese strains of group A streptococci. Zhurn. Microbiol. 2018.T 2. – 23p. doi.org/10.36233/0372-9311-2018-2-23-30 https://microbiol.elpub.ru/jour/article/view/262?locale=ru_RU
  • Belopolskaya M.A., Avrutin V.Yu., Denisova O.D., Personal E.V., Yushina E.Yu., Gurina S.I., Dmitriev A.V., Yakovlev A.A. Compression elastography and its use in clinical practice in comparison with other methods for assessing the degree of fibrosis in liver tissue in patients with chronic hepatitis C. Zhurn. infectology, 2018. T 10 No. 3. – 84p. DOI: 10.22625 / 2072-6732-2018-10-3-84-90 https://journal.niidi.ru/jofin/article/view/762
  • Makarova M.A., Dmitriev A.V., Matveeva Z.N., Kaftyreva L.A. Molecular genetic characteristics of Escherichia coli serogroup O26 strains causing diarrheal diseases in children. Medical academic journal. 2018. T 18 No.3. – 85p. DOI: 10.17816 / MAJ18385-90 https://journals.eco-vector.com/MAJ/article/view/10937
  • Milman B.L., Gostev V.V., Dmitriev, A.V. A comparison of “low-molecular” and conventional approaches to the species identification of bacteria by MALDI mass spectrometry. J. Anal. Chem. 2018. T 73 No. 13. – 1217p. DOI: 10.1134 / S1061934818130105 https://link.springer.com/article/10.1134/S1061934818130105
  • Belopolskaya M.A., Grigorieva T.D., Avrutin V.Yu., Potanina D.V., Dmitriev A.V., Yakovlev A.A. Strength of immunity to measles in different population groups. Journal. infectology, 2020. T 12 No. 1. 80s. doi.org/10.22625/2072-6732-2020-12-1-80-84 https://journal.niidi.ru/jofin/article/view/1016
  • Perepelina K., Kostina A., Klauzen P., Khudiakov A., Rabino M., Crasto S., Zlotina A., Fomicheva Yu., Sergushichev A., Oganesian M., Dmitriev A., Kostareva A., Pasquale E .Di, Malasicheva A. Generation of two iPSC lines (FAMRCi007-A and FAMRCi007-B) from patient with Emery-Dreifuss muscular dystrophy and heart rhythm abnormalities carrying genetic variant LMNA p.Arg249Gln. Stem Cell Res. 2020.T 47. – 101895s. doi: 10.1016 / j.scr.2020.101895 https://pubmed.ncbi.nlm.nih.gov/32659731/ https://www.sciencedirect.com/science/article/pii/S1873506120301963?via%3Dihub
  • Golovkin A.S., Kudryavtsev I.V., Dmitriev A.V., Kalinina O.V. Fibrous changes in the cardiovascular and respiratory systems after suffering COVID-19: the contribution of immune system factors and genetic predisposition. Russian journal of cardiology. 2020.Vol. 25 No. 10. – 214p. DOI: 10.15829 / 1560-4071-2020-4087

Scientific and educational center ‘Molecular bases of interaction of microorganisms and humans’ WCRC ‘Center for Personalized Medicine’

Competence centers
Peptide Engineering Competence Center
Competence Center ‘Microbial Therapy’
Departments
Department of Scientific Projects Support
Department of Microbial Therapy
Laboratories within the department of microbial therapy
Laboratory of Oncolytic bacteria
Laboratory for Vaccine Prevention of Infectious Diseases
Laboratory of Personalized Microbial Therapy
Separate laboratories
Laboratory of Alternative Antimicrobial Biologicals
Laboratory for innovative methods of microbiological monitoring

NEWS of WCRC ‘Center for Personalized Medicine’

The Institute of Experimental Medicine held a seminar ‘Antimicrobial peptides as prototypes of new antibiotics’

The seminar is timed to coincide with the Year of Science, as well as the opening of the Peptide Engineering Competence Center, created as part of the development of the Molecular Basics of Interaction of Microorganisms and Human Research Center, the Center for Personalized Medicine, operating on the basis of the Institute of Experimental Medicine.

On the 19th of July 19, 2021, as part of the development of the WCRC ‘Center for Personalized Medicine’, the FSBSI ‘IEM’ opened a center of competence ‘Peptide Engineering’.

The opening of the CC was associated with a seminar with international participation on the topic ‘Antimicrobial peptides as prototypes of new antibiotics’.

TASS: WCRC in St. Petersburg will develop new antibacterial drugs and vaccines

On the TASS timeline in the section NATIONAL PROJECTS: SCIENCE-WCRC-PREPARATIONS-VACCINES, material was published on the WCRC ‘Personalized Medicine’ and the tasks facing the Institute of Experimental Medicine, which is part of this consortium.

A.V. Dmitriev gave an interview about the creation of the WCRC ‘Center for Personalized Medicine’

Watch the video of the interview with the director of the Institute of Experimental Medicine.

‘Center for Personalized Medicine’. A new structural unit has been created.

A new structural unit was created at the FSBSI ‘Institute of Experimental Medicine’ – the Scientific and Educational Center ‘Molecular Foundations of Interaction between Microorganisms and Human’ within the framework of the within the framework of the creation and development of the world-class research Center ‘Center for Personalized Medicine’.

10 world-class research centers in 6 priority areas received state support

The Institute of Experimental Medicine received support in the direction of ‘Personalized medicine, high-tech healthcare and health-preserving technologies’