I.P. Pavlov Department of Physiology

Head of the Department

Abdurasulova Irina Nikolaevna,
кандидат биологических наук

e-mail: abdurasulova.i@iemspb.ru

Phone: (812) 234-94-75

The Department consists of:

History of I.P. Pavlov Department of Physiology

The Department of Physiology was organized one of the first as part of the Imperial Institute of Experimental Medicine in 1891, and from the very beginning it was headed by Professor I.P. Pavlov, who later became a Nobel Prize laureate in 1904, became an academician in 1908 and an internationally recognized scientist. I.P. Pavlov proceedings are rightfully considered as classical, which had opened new pages in almost all major sections of Physiology and Medicine.

The main distinguishing feature of I.P. Pavlov’s art is a theory of Nervism. The main idea of this theory is that nervous system plays a decisive role in regulating the functional state and activity of all organs and systems of the body. The Department carried out studies under his leadership, which enriched world science with data on the functioning of the digestive tract, opened conditioned reflexes, substantiated experimental modeling of Neurosis and created the theory of higher nervous activity (behavior), which until now underlies scientific ideas in Physiology, Neurology, Psychophysiology, Psychiatry and Psychology. However, not only I.P. Pavlov took part in the creation of the Russian Psycho-neurological Scientific School, he was helped by his closest associates as D.L. Glinsky, S.G. Wolfson and A.T. Snarsky and his an outstanding students P.K. Anokhin, E.A. Astratyan, B.P. Babkin, D.A. Biryukov, K.M. Bykov, V.S. Deryabin, I.V. Zavadsky, N.I. Krasnogorsk, A.N. Krestovikov, P.S. Kupalov, L.A. Orbeli, N.A. Rozhansky, V.V. Savich, G.V. Folbort, I.S. Tsitovich and others who later formed the elite of the domestic Physiology.

After I.P. Pavlov’s death in 1936, Academician of the Academy of Medical Sciences of the USSR P.S. Kupalov became the head of the Department (1937–1964);  academician of the Academy of Medical Sciences of the USSR M.M. Khananashvili  became the head of the Department (1965–1976); corresponding member of the Academy of Medical Sciences of the USSR G.A. Vartanyan was the head of the Department too (1976–1995). Professor V.M. Klimenko has been heading the Department since 1995.

The main areas of research

The main focus of research is on the connection between the body and the environment, the processing of sensory information, its significance for social experience and, more generally, the normal and pathological mechanisms of the central nervous system, and, in particular, the mechanisms of cognitive functions and integrative brain activity.

There are also works in the sphere of studying the mechanisms of disorders, which underlying the regulation of the central nervous system response to adverse environmental factors, the formation of neurodegenerative diseases, mental disorders and minimal brain dysfunctions.

There is a search for new treatment strategies that can influence cell differentiation processes, stimulate neurogenesis and normalize trophic functions in the central nervous system in socially significant diseases such as Multiple Sclerosis, Parkinson’s and Alzheimer’s diseases, Ischemic and Traumatic brain injuries, Attention deficit  and Hyperactivity disorder in children.

Main Academic Results

The connection between the main pathogenic processes that trigger the death of nerve cells in various neurodegenerative diseases: neuroinflammation, excitotoxicity and oxidative stress.

It is proved that the proinflammatory cytokines secreted by activated lymphocytes and monocytes during inflammatory processes of any etiology act in the brain mediate the central components of the body’s response to activation of the immune system, defining the standard set of patient’s behavioral responses, which is called ‘sickness behavior’ in international literature.

It is proved that a moderate increase in the level of IL-1 at the critical time of early postnatal ontogenesis leads to long-term (detected in adult animals) changes in research behavior and various types of memory.

The presence of neurodegeneration is proved in the autoimmune CNS pathology. The conjugation of the action of inflammatory and excitotoxic factors is shown, the involvement of glutamate receptors in this process is revealed, methods of neuroprotection using NMDA and / or AMPA receptor blockers and suppression of the hyperactivation of the calpain system using calpastatin mimetics are developed.

Priority data were obtained on the protective and stress-limiting properties of the galanin neuropeptide. Allelic variants of the galanin gene in Wistar rats and peculiarities of the reaction to stress and the administration of neurotoxins in animals with differences in the structure of the promoter region of the galanin gene were revealed.

New mechanisms of calpain involvement in the regulation of the activity of the dopaminergic system in the normal state and during the development of Parkinson’s disease were identified.

It is proved that cognitive and emotional disturbances during Alzheimer’s disease can be associated with an increase in the phase release of dopamine in the shell of the adjacent nucleus and its simultaneous weakening in the dorsal striatum.

It was shown that the experience of a single psychological trauma caused by a real threat to life leads to long-lasting structural and functional disorders in the brain, inhibition of proliferative stem cell proliferation in the brain, systemic impairment of lipid metabolism by atherogenic type, motor and emotional disorders in the offspring. The possibility of correcting disorders was identified after mental and physical trauma using vasopressin preparations is shown.

The International Cooperation

Since 2004, the I.P. Pavlov Department of Physiology participates in the organization of the major annual international conference on Neurobiology and Psychiatry ‘Stress and behavior’ in conjunction with the International Stress and Behavior Society.

Theses of the research assistants of the department over the past 5 years

Doctorate theses:

Candidate’s theses:

Academic titles received by the research assistants of the department over the past 5 years:

Patents obtained by the research assistants of the department over the past 5 years:

Technologies obtained by the research assistants of the department over the past 5 years:

  1. Авалиани Т. В., Быкова А. В., Цикунов С. Г. Технология профилактики стрессорной реакции при психогенной травме // Информ. реестр нов. технологий профилактики, диагностики, лечения и реабилитации ФГБНУ «ИЭМ». Рег. № 17001-п от 10.11.2017.
  2. Цикунов С. Г., Белокоскова С. Г. Технология коррекции недостаточности мозгового кровообращения посредством нейропептида аргинин-вазопрессина в условиях стентирования мозговых артерий // Информ. реестр нов. технологий профилактики, диагностики, лечения и реабилитации ФГБНУ «ИЭМ». Рег. № 557/15-112-л от 24.12.2015. Свид-во о регистрации нов. технологии № НТ-00039 выдано в 2016 г.
  3. Белокоскова С. Г., Цикунов С. Г. Технология восстановления чувствительности после инсультов и травм мозга // Информ. реестр нов. технологий профилактики, диагностики, лечения и реабилитации ФГБНУ «ИЭМ». Рег. № 557-15001-л от 15.04.2015. Свид-во о регистрации нов. технологии № НТ-0034 выдано 21.12.2015.
  4. Белокоскова С. Г., Цикунов С. Г. Технология лечения расстройств речи у больных с афазией // Информ. реестр нов. технологий профилактики, диагностики, лечения и реабилитации ФГБНУ «ИЭМ». Рег. № 557-1405-л от 09.09.2014. Свид-во о регистрации нов. технологии № НТ-0007 выдано 12.02.2015.

The most significant publications over the past 5 years

  1. Muruzheva Z. M., Ivleva I. S., Traktirov D. S., Zubov A. S., Karpenko M. N. The relationship between serum interleukin-1β, interleukin-6, interleukin-8, interleukin-10, tumor necrosis factor-α levels and clinical features in essential tremor // Int J Neurosci. 2022. 132(11):1143-1149. DOI: 10.1080/00207454.2020.1865952.
  2. Трусов Н. В., Семин М. О., Шипелин В. А., Апрятин С. А., Гмошинский И. В. Экспрессия генов в печени крыс, получавших с рационом комплекс ресвератрола и L-карнитина, в норме и при ожирении // Вопросы питания. 2021. Т. 90 № 5. С. 25-37. DOI: 10.33029/0042-8833-2021-90-5-25-37.
  3. Никитина В. А., Захарова М. В., Трофимов А. Н., Шварц А. П., Безнин Г. В., Цикунов С. Г., Зубарева О. Е. Действие неонатальных введений бактериального эндотоксина на поведение и экспрессию генов ионотропных рецепторов глутамата в гиппокампе взрослых крыс после психогенной травмы // Биохимия 2021; 86 (6):904-916. DOI: 10.31857/S0320972521060129.
  4. Zhukov I. S., Kubarskaya L. G., Karpova I. V., Vaganova A. N., Karpenko M. N., Gainetdinov R. R. Minor Changes in Erythrocyte Osmotic Fragility in Trace Amine-Associated Receptor 5 (TAAR5) Knockout Mice // Int J Mol Sci. 2021. 7;22(14):7307. DOI: 10.3390/ijms22147307.
  5. Muruzheva Z. M., Traktirov D. S., Zubov A. S., Pestereva N. S., Tikhomirova M. S., Karpenko M. N. Calpain activity in plasma of patients with essential tremor and Parkinson’s disease: a pilot study // Neurol Res. 2021 Apr 43(4): 314-320. DOI: 10.1080/01616412.2020.1854004.
  6. Апрятин С. А., Жуков И. С., Манасян А. Л., Муртазина Р. З., Хунагов Т. А., Лезина А. И., Клименко В. М. Влияние высокофруктозной диеты на физиологические, биохимические и морфологические показатели самок крыс нокаутной линии TAAR9-KO // Российский физиологический журнал им. И.М. Сеченова.- 2021. Т. 107. №10. DOI: 10.31857/S0869813921100022
  7. Murtazina R. Z., Zhukov I. S., Korenkova O. M., Popova E. A., Kuvarzin S. R., Efimova E. V., Kubarskaya L. G., Batotsyrenova E. G., Zolotoverkhaya E. A., Vaganova A. N., Apryatin S. A., Alenina N. V., Gainetdinov R. R. Genetic Deletion of Trace-Amine Associated Receptor 9 (TAAR9) in Rats Leads to Decreased Blood Cholesterol Levels // International Journal of Molecular Sciences. 2021. Vol. 22. Issue 6. P. 2942. DOI: 10.3390/ijms22062942
  8. Gromova L. V., Fetissov S. O., Gruzdkov A. A. Mechanisms of Glucose Absorption in the Small Intestine in Health and Metabolic Diseases and Their Role in Appetite Regulation // Nutrients. 2021. 13(7): 2474. DOI: 10.3390/nu13072474
  9. Maystrenko V., Ivleva I., Krytskaya D., Zubov A., Ivlev A., Karpenko M. Changes in activity of µ- and m-calpains and signs of neuroinflammation in the hippocampus and striatum of rats after single intraperitoneal injection of subseptic dose of endotoxin // Metab Brain Dis. 2021. 36(7):1917-1928. DOI: 10.1007/s11011-021-00755-y.
  10. Pestereva N., Ivleva I., Zubov A., Tikhomirova M., Karpenko M. m-Calpain is released from striatal synaptosomes // Int J Neurosci. 2021 Mar 31:1-7. DOI: 10.1080/00207454.2021.1901697.
  11. Фетисов С.О. О роли кишечных бактерий в физиологической регуляции аппетита и энергетического обмена // Интегративная физиология. 2021. Т. 2. № 1. С. 21-32 DOI: 10.33910/2687-1270-2021-2-1-21-32.
  12. Mukhin V. N., Borovets I. R., Sizov V. V., Pavlov K. I., Klimenko V. M. Differential Influence of Amyloid-β on the Kinetics of Dopamine Release in the Dorsal and Ventral Striatum of Rats // Neurotoxicity Research. 2021. 39(4), 1285-1292. DOI:10.1007/s12640-021-00371-9.
  13. Павлов К. И., Мухин В. Н. Физиологические механизмы нейропластичности как основа психических процессов и социально-профессиональной адаптации (часть 1) // Психология. Психофизиология. 2021. Т 14. № 3. С. 119-136 DOI:10.14529/jpps210312.
  14. Павлов К. И., Петренко М. И., Мухин В. Н., Сырцев А. В., Архимук А. Н. Психофизиологические предикторы военно-профессиональной адаптации курсантов первого курса военно-морского института // Психология образования в поликультурном пространстве. 2021. № 1(53). С. 18-36. DOI:10.24888/2073-8439-2021-53-1-18-36.
  15. Мухин В.Н., Боровец И.Р., Сизов В.В., Павлов К.И., Клименко В.М. β-Амилоид и литий влияют на секрецию дофамина в оболочке прилежащего ядра // Журнал высшей нервной деятельности им. И. П. Павлова. 2020. Т. 70. № 4. С. 488-499. DOI: 10.31857/S0044467720040073.
  16. Lioudyno V., Abdurasulova I., Negoreeva I., Stoliarov I., Kudryavtsev I., Serebryakova M., Klimenko V., Lioudyno M. Common genetic variant rs2821557 in KCNA3 is linked to a severity of multiple sclerosis // Journal of Neuroscience Research. 2021. 99(1):200-208. DOI: 10.1002/jnr.24596.
  17. Клюева Н.Н., Авалиани Т.В., Апраксина Н.К. Липидный спектр у потомства крыс в модели прекондиционирования психотравмирующего воздействия // Обзоры по клинической фармакологии и лекарственной терапии, 2020, 18(1):57–62. DOI: 10.17816/RCF18157-61.
  18. Цейликман В.Э., Комелькова М.В., Лапшин М.С., Цейликман О.Б., Карпенко М.Н., Пестерева Н.С., Манухина Е.Б., Дауни Г.Ф., Кондашевская М.В. Содержание моноаминов нейротрансмиттеров в варолиевом мосту при экспериментальном синдроме посттравматических стрессорных расстройств // Нейрохимия. 2020. 37(1), 750–779. DOI: 10.31857/s1027813320010185.
  19. Апрятин С.А., Карпенко М.Н., Муружева З.М., Большакова М.В., Клименко В.М. Нейродегенеративные и метаболические нарушения, опосредованные следовыми аминами и их рецепторами // Медицинский академический журнал. 2020. Т. 20. № 1. С. 9–22. DOI: 10.17816/MAJ25746.
  20. Трофимов А.Н., Ротов А.Ю., Вениаминова Е.А., Фомалонт К., Шварц А.П., Зубарева О.Е. Изменение поведения и экспрессии генов ионотропных рецепторов глутамата в мозге взрослых крыс после неонатальных введений бактериального липополисахарида // Российский физиологический журнал им. И.М. Сеченова. 2020. 106(3):356–372. DOI: 10.31857/S0869813920030097.
  21. Abdurasulova I.N., Ekimova I.V., Chernyshev M.V., Matsulevich A.V., Pastukhov Yu.F. Impairment to Cognitive Functions in Wistar Rats in a Model of the Preclinical Stage of Parkinson’s Disease // Neurosci and Behavioral Physiol. 2020; 50(4): 439-450. DOI: 10.1007/s11055-020-00919-w.
  22. Tseilikman V., Komelkova M., Lapshin M., Alliluev A., Tseilikman O., Karpenko M., Pestereva N., Manukhina E., Downey H. F., Kondashevskaya M., Sarapultsev A., & Dremencov E. High and low anxiety phenotypes in a rat model of complex post-traumatic stress disorder are associated with different alterations in regional brain monoamine neurotransmission // Psychoneuroendocrinology. 2020. 117:104691. DOI: 10.1016/j.psyneuen.2020.104691.
  23. Manukhina E.B., Tseilikman V.E., Karpenko M.N., Pestereva N.S., Tseilikman O.B., Komelkova M.V., Kondashevskaya M.V., Goryacheva A.V., Lapshin M. S., Platkovskii P.O., Sarapultsev A.P., Alliluev AV., Fred Downey H. Intermittent hypoxic conditioning alleviates post-traumatic stress disorder-induced damage and dysfunction of rat visceral organs and brain // International Journal of Molecular Sciences. 2020. 5; 21(1):345. DOI: 10.3390/ijms21010345.
  24. Kropotova E.S., Ivleva I.S., Karpenko M.N., Mosevitsky M.I. Design of enkephalin modifications protected from brain extracellular peptidases providing long-term analgesia // Bioorganic and Medicinal Chemistry. 2020. 1;28 (1):115184. DOI: 10.1016/j.bmc.2019.115184.
  25. Zubov A., Muruzheva Z., Tikhomirova M., Karpenko M. Glibenclamide as a neuroprotective antidementia drug // Archives of Physiology and Biochemistry. 2020. 11; 1-4. DOI: 10.1080/13813455.2020.1789170.
  26. Ivleva I., Pestereva N., Zubov A., Karpenko M. Intranasal exposure of manganese induces neuroinflammation and disrupts dopamine metabolism in the striatum and hippocampus // Neuroscience Letters. 2020. 1; 738:135344. DOI: 10.1016/j.neulet.2020.135344.
  27. Lioudyno V., Abdurasulova I., Tatarinov A., Nikiforova I., Ilves A., Ivashkova E., Stoliarov I., Bisaga G., Klimenko V. The effect of galanin gene polymorphism RS948854 on the severity of multiple sclerosis course: a significant association with the age of onset // Multiple sclerosis and related disorders. 2020. 37: C. 101439. DOI: 10.1016/j.msard.2019.101439.
  28. Abdurasulova I.N., Matsulevich A.V., Kirik O.V., Tarasova E.A. Ermolenko E.I., Korzevskii D.E., Klimenko V.M., Di Pierro F., Suvorov A.N. The protective effect of Enterococcus faecium L-3 in experimental allergic encephalomyelitis in rats is dose-dependent // Nutrafoods, 2019, 1:1–11. DOI 10.17470/NF-019-0001.