Laboratory of Functional Genomics and Proteomics of Microorganisms

Head of the Laboratory

Goncharov Artemiy Evgen’evich,
доктор медицинских наук, доцент


The laboratory was established in 2008.


The main objects of research are pathogenic and conditionally pathogenic streptococci – pathogens of infectious diseases of humans and animals.


The main areas of research:


– studying of genomic polymorphism of pathogenic bacteria;

– development of molecular diagnostics of pathogens;

– studying of the mechanisms of regulation of gene transcription and expression of proteins of microorganisms;

– creation on the basis of streptococcal proteins of unique sorbents and diagnostic kits for detecting the content of albumin and immunoglobulins of various classes in human biological fluids.


The most significant results obtained in recent years:

– new molecular approaches have been developed for differential gene diagnostics of epidemiologically relevant clones of streptococci of various species (S. agalactiae, S. pyogenes, S. pneumoniae, S. dysgalactiae, S. uberis, S. mutans, S. constellatus, S. equisimilis);

– genetic maps of streptococcus strains were constructed, previously unknown virulence genes and ‘pathogenicity islands’ were discovered, and new markers were identified to determine the degree of genetic affinity of the strains;

– the mechanisms of regulation of the expression of virulence genes of S. pyogenes (protein-regulators Rgg, MutR), S. agalactiae (two-component BgrR / S system), S. mutans (protein-regulator CovR) and their effect on the pathogenic properties of streptococci were studied.


Series of studies on the mechanisms of regulation of gene expression in pathogenic streptococci was awarded the Prince of Oldenburg Prize.


The principle of receptor-enzyme analysis was developed with the participation of Doctor of Biological Sciences T.V. Gupalova. A highly sensitive method was formed on its basis. This method is rather famous in clinical practice for assessing the status and prognosis of the development of possible kidney damage in patients with diabetes mellitus with microalbuminuria. An experimental diagnostic test system has been created and tested, as well as producer strains of polypeptides that bind albumin and immunoglobulin G.

Research Assistants of the Laboratory